I don't know who this Dr. Aston is, but I've never heard of harmful effects from long-term use of BOTOX. I work in plastic surgery, and I just don't understand why anyone would think that a company as big as Allergan (maker of BOTOX) would risk it's future by putting out a product with long-term health implications. To me, the biggest "risk" is that eventually injectable treatments may not be able to sufficiently correct the steady sagging of your skin, requiring a brow lift or face lift in Indianapolis or wherever it is you're from. BOTOX is safe and has been used to treat a variety of conditions for several decades.