There's a slightly frightening comment by Dr. Aston about the risks of using Botox or other injectibles over a long time period. He's quoted in the Guardian as saying;

'I think for people that do it over and over, this is worrying... we have seen some of these people already. A lot of these injectibles were available in Europe, you know, about six years ago. So I've seen ladies now, who started at that time, who are having some skin changes.' His voice drops, as if he's predicting a major tragedy. 'And that's what's going to make us start to look very carefully at everybody who is showing the effect.'